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System-wide identification and prioritization of enzyme substrates by thermal analysis
- Source :
- Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- The global identification of enzyme substrates is still challenging. Here, the authors develop a method based on proteome-wide thermal shift assays to discover enzyme substrates directly from cell lysates, identifying known and novel oxidoreductase, kinase and poly-(ADP-ribose) polymerase substrates.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 24403687
- Volume :
- 12
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.565c329cae24403687890498fa03809d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-021-21540-6