Value of real-time tissue elastography in evaluating donor liver quality and postoperative early allograft dysfunction in liver transplantation patients

Objective To investigate the value of real-time tissue elastography (RTE) in evaluating donor liver quality and postoperative early allograft dysfunction (EAD) in liver transplantation patients. Methods A total of 58 patients who received liver transplantation in Organ Transplantation Center of our hospital from October 2020 to January 2022 were enrolled, and according to the recovery of liver function in the early stage after surgery, the patients were divided into EAD group and non-EAD group. The two groups were compared in terms of the indicators such as the routine ultrasound examination and RTE measurement of donor liver before liver transplantation, liver function and coagulation function of recipients before and after liver transplantation, and preoperative Model for End-Stage Liver Disease (MELD) score. The logistic regression analysis was performed for the indicators with significant differences, and the receiver operating characteristic (ROC) curve was plotted to calculate the area under the ROC curve (AUC) and assess the performance of related factors. Results Compared with the non-EAD group, the EAD group had significantly higher liver fibrosis (LF) index of donor liver and MELD score of recipients (t=4.822, 2.902,P1.645 was a risk factor for EAD after liver transplantation, and the ROC curve analysis showed that donor liver LF index had an AUC of 0.840 in predicting EAD after surgery, with a sensitivity of 82.4%, a specificity of 73.2%, and a cut-off value of 1.645. Conclusion High LF index of donor liver before liver transplantation is a risk factor for EAD in recipients after liver transplantation, and RTE measurement for LF index of donor liver before li-ver transplantation has a certain value in assessing the quality of donor liver and predicting the onset of EAD.