Ameliorating Effect of Polyphenol Extract of Rosa roxburghii on Obese Mice Induced by High Fat Diet

Objective: To investigate the beneficial effects of phenolic extracts of Rosa roxburghii Tratt. on obese mice induced by a high-fat diet. Methods: The intervention involved administering polyphenol extract at a dose of 400 mg/kg body weight per day to mice on a high-fat diet. The mice were orally gavaged continuously for 4 weeks, and various parameters such as body weight, liver index, histomorphological changes in white fat and liver tissues, serum biochemical markers, organ antioxidant capacity, and intestinal barrier function were examined. Results: In comparison to control group (CON), the MODEL group (MODEL) exhibited significantly (P