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A Graphical Notation to Describe the Logical Interactions of Biological Pathways

Authors :
Moodie Stuart L.
Sorokin Anatoly
Goryanin Igor
Ghazal Peter
Source :
Journal of Integrative Bioinformatics, Vol 3, Iss 2, Pp 177-187 (2006)
Publication Year :
2006
Publisher :
De Gruyter, 2006.

Abstract

The modelling of biological intra-cellular pathways requires the systematic capture and representation of interactions between components that are biologically correct and computationally rigorous. The challenge is two fold, to verify and extend our understanding of such pathways by comparing in silico models to experiments; and to ensure that such models are understandable by biologists and for checking biological validity. In this report we present a graphical notation, the Edinburgh Pathway Notation (EPN), which satisfies the central biologically driven requirements while providing a strict formal framework for analysis. The EPN emphasises the use of a logical representation of pathways, which is particularly suited to pathways were some mechanisms are not known in detail.

Subjects

Subjects :
Biotechnology
TP248.13-248.65

Details

Language :
English
ISSN :
16134516
Volume :
3
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Journal of Integrative Bioinformatics
Publication Type :
Academic Journal
Accession number :
edsdoj.571637261254110be6c895dee5ac180
Document Type :
article
Full Text :
https://doi.org/10.1515/jib-2006-36