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Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke

Authors :
Eckhard Schlemm
Thies Ingwersen
Alina Königsberg
Florent Boutitie
Martin Ebinger
Matthias Endres
Jochen B. Fiebach
Jens Fiehler
Ivana Galinovic
Robin Lemmens
Keith W. Muir
Norbert Nighoghossian
Salvador Pedraza
Josep Puig
Claus Z. Simonsen
Vincent Thijs
Anke Wouters
Christian Gerloff
Götz Thomalla
Bastian Cheng
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

The effects of thrombolysis therapy in stroke on structural connectivity are not well understood. Here, the authors show with causal mediation analysis that the clinical benefits of thrombolysis in anterior circulation stroke are mediated via structural connectivity.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.57258b4e8c144513a87b692fc69385cf
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-22786-w