The role of Mediator and Little Elongation Complex in transcription termination

Authors :: Hidehisa Takahashi
Amol Ranjan
Shiyuan Chen
Hidefumi Suzuki
Mio Shibata
Tomonori Hirose
Hiroko Hirose
Kazunori Sasaki
Ryota Abe
Kai Chen
Yanfeng He
Ying Zhang
Ichigaku Takigawa
Tadasuke Tsukiyama
Masashi Watanabe
Satoshi Fujii
Midori Iida
Junichi Yamamoto
Yuki Yamaguchi
Yutaka Suzuki
Masaki Matsumoto
Keiichi I. Nakayama
Michael P. Washburn
Anita Saraf
Laurence Florens
Shigeo Sato
Chieri Tomomori-Sato
Ronald C. Conaway
Joan W. Conaway
Shigetsugu Hatakeyama
Source :: Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Publication Year :: 2020
Publisher :: Nature Portfolio, 2020.
Abstract: Mediator subunit MED26 was shown to help recruit Super Elongation Complex (SEC) or Little Elongation Complex (LEC) to control the expression of certain genes. Here, the authors provide evidence that MED26 recruits LEC to regulate transcription termination of non-polyadenylated genes, including snRNA and replication-dependent histone (RDH) genes at Cajal bodies.

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