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Case series: COVID-19 in patients with mild to moderate myasthenia gravis in a National Referral Hospital in Indonesia

Authors :
Fitri Octaviana
Hardito Puspo Yugo
Ahmad Yanuar Safri
Luh Ari Indrawati
Winnugroho Wiratman
Triana Ayuningtyas
Manfaluthy Hakim
Source :
eNeurologicalSci, Vol 23, Iss , Pp 100332- (2021)
Publication Year :
2021
Publisher :
Elsevier, 2021.

Abstract

Background: During the COVID-19 pandemic, patients with myasthenia gravis (MG) are most likely to be affected by this situation. Corticosteroids and immunosuppressant agents increase the risk of severe infection. Furthermore, viral infection and some medications in COVID-19 may exacerbate MG symptoms. Case description: We presented three patients with MG who contracted COVID-19. All of the patients had a favourable outcome. Only one patient who was not treated with corticosteroids or immunosuppressant therapy experienced deterioration of MG symptoms, while the other patients who received immunosuppressant therapy did not develop MG exacerbation. Surprisingly, azithromycin did not provoke myasthenic crisis (MC) in patients with normal MGFA classification. Conclusion: Using immunosuppressant agents may not lead to MG deterioration and may not be related to unfavourable outcomes.

Details

Language :
English
ISSN :
24056502
Volume :
23
Issue :
100332-
Database :
Directory of Open Access Journals
Journal :
eNeurologicalSci
Publication Type :
Academic Journal
Accession number :
edsdoj.574cdd82a7f412d9c224b8a8fab3a3c
Document Type :
article
Full Text :
https://doi.org/10.1016/j.ensci.2021.100332