Back to Search Start Over

The Same–Up–Down Staging System for Recurrent Early Glottic Cancer

Authors :
Giuseppe Licci
Luca Giovanni Locatello
Giandomenico Maggiore
Flavia Cozzolino
Saverio Caini
Oreste Gallo
Source :
Cancers, Vol 15, Iss 3, p 598 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

(1) Background: The treatment of recurrent early glottic cancer (rEGC) remains challenging. We wanted to investigate how the oncological outcomes are affected by the initial and recurrent stages, in order to propose our newly developed Same–Up–Down (SUD) staging system. (2) Methods: In our cohort of 258 rEGC patients, we retrospectively assessed the prognostic performances of the rTNM (the TNM staging system for recurrence), CLRSS, CLRSS-2, and SUD staging systems by univariate and multivariate Cox analysis, comparing their predictive capability using Harrell’s C-index. (3) Results: The SUD classification satisfactorily predicted both overall survival (p = 0.022) and second-recurrence-free survival (p = 0.024, as same + down vs. upstage) in our cohort. It also outperformed the other three systems in terms of prediction of survival, with an improvement of 1.52%, 1.18%, and 3.96% in the predictive capacity of overall survival, disease-specific survival, and second-recurrence-free survival, respectively. (4) Conclusions: The SUD staging system can efficiently predict survival in rEGC patients, whose prognosis heavily depends on both the initial and recurrent locoregional extension.

Details

Language :
English
ISSN :
15030598 and 20726694
Volume :
15
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Cancers
Publication Type :
Academic Journal
Accession number :
edsdoj.57c839388a8e4bb8b056a2546d2d7a47
Document Type :
article
Full Text :
https://doi.org/10.3390/cancers15030598