Back to Search Start Over

Structural variant-based pangenome construction has low sensitivity to variability of haplotype-resolved bovine assemblies

Authors :
Alexander S. Leonard
Danang Crysnanto
Zih-Hua Fang
Michael P. Heaton
Brian L. Vander Ley
Carolina Herrera
Heinrich Bollwein
Derek M. Bickhart
Kristen L. Kuhn
Timothy P. L. Smith
Benjamin D. Rosen
Hubert Pausch
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Pangenomes have a number of advantages over linear reference assemblies. Here the authors use bovine haplotype-resolved assemblies to show that structural variant-based pangenomes are consistent regardless of sequence platform, assembler, or coverage, suggesting that rigid protocols may not be required.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.57ff639592064173af9b68fcf0522c73
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-30680-2