Back to Search Start Over

Nail changes caused by chemotherapy among cancer patients: A cross-sectional study of northwest rajasthan

Authors :
Madhvi Trivedi
R D Mehta
H S Kumar
B C Ghiya
Prasoon Soni
Manish Kumar Meena
Vineet Kumar
S Rekha
Source :
Indian Dermatology Online Journal, Vol 11, Iss 6, Pp 953-958 (2020)
Publication Year :
2020
Publisher :
Wolters Kluwer Medknow Publications, 2020.

Abstract

Background: The nail changes caused by chemotherapy in cancer patients are difficult to assess and often overlooked by clinician. The present study was undertaken to study nail changes caused by various chemotherapeutic agents and various drug protocols most commonly associated with them. Materials and Method: Five hundred patients with malignancies receiving chemotherapy in the oncology ward and skin outpatient department were screened in this cross-sectional observational study from November 2018 to October 2019. Results: Nail changes due to chemotherapy were observed in 37.6% patients. The most common condition observed was melanonychia (84.04%), followed by half and half nails (6.91%), erythronychia (5.31%), longitudinal grooves (2.12%), leukonychia (2.12%), Mees’ lines (1.59%), Beau's lines (0.53%), pitting (0.53%), and subungual hyperkeratosis (0.53%). The usual protocol to cause melanonychia was platinum analogues + taxanes based combinations, half and half nails by platinum analogues + taxanes + 5 fluorouracil (5FU) based polypharmacy, and erythronychia by cisplatin-based adjuvants. Conclusion: The knowledge of the nail changes caused by chemotherapy will help in counseling of already worried patients with malignancy. It will also improve patient compliance and enrich the clinicians’ knowledge pertaining to chemotherapy-induced nail changes.

Details

Language :
English
ISSN :
22295178
Volume :
11
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Indian Dermatology Online Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.58fb4fecf34ae4a8491e41664f683c
Document Type :
article
Full Text :
https://doi.org/10.4103/idoj.IDOJ_84_20