A comprehensive expression analysis of mucins in appendiceal carcinoma in a multicenter study: MUC3 is a novel prognostic factor.

Authors :: Hiroaki Shibahara
Michiyo Higashi
Seiya Yokoyama
Karine Rousseau
Iwao Kitazono
Masahiko Osako
Hiroshi Shirahama
Yukie Tashiro
Yasuhiro Kurumiya
Michihiko Narita
Shingo Kuze
Hiroshi Hasagawa
Takehito Kato
Hitoshi Kubota
Hideaki Suzuki
Toshiyuki Arai
Yu Sakai
Norihiro Yuasa
Masahiko Fujino
Shinji Kondo
Yoshichika Okamoto
Tatsuyoshi Yamamoto
Takashi Hiromatsu
Eiji Sasaki
Kazuhisa Shirai
Satoru Kawai
Koutarou Hattori
Hideki Tsuji
Osamu Okochi
Masaki Sakamoto
Akinobu Kondo
Naomi Konishi
Surinder K Batra
Suguru Yonezawa
Source :: PLoS ONE, Vol 9, Iss 12, p e115613 (2014)
Publication Year :: 2014
Publisher :: Public Library of Science (PLoS), 2014.
Abstract: Mucins are implicated in survival in various cancers, but there have been no report addressed on survival in appendiceal carcinoma, an uncommon disease with different clinical and pathological features from those of other colon cancers. We aimed to investigate the clinical implications of expression of mucins in appendiceal carcinoma.Expression profiles of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC6, MUC16 and MUC17 in cancer tissue were examined by immunohistochemistry in 108 cases of surgically resected appendiceal carcinoma.The following relationships of mucins with clinicopathologic factors were identified: MUC1 with positive lymphatic invasion (p = 0.036); MUC2 with histological type (mucinous carcinoma, p

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