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Circulating concentrations of bile acids and prevalent chronic kidney disease among newly diagnosed type 2 diabetes: a cross-sectional study

Authors :
Tingting Geng
Qi Lu
Limiao Jiang
Kunquan Guo
Kun Yang
Yun-Fei Liao
Meian He
Gang Liu
Huiru Tang
An Pan
Source :
Nutrition Journal, Vol 23, Iss 1, Pp 1-9 (2024)
Publication Year :
2024
Publisher :
BMC, 2024.

Abstract

Abstract Background The relationship between circulating bile acids (BAs) and kidney function among patients with type 2 diabetes is unclear. We aimed to investigate the associations of circulating concentrations of BAs, particularly individual BA subtypes, with chronic kidney disease (CKD) in patients of newly diagnosed type 2 diabetes. Methods In this cross-sectional study, we included 1234 newly diagnosed type 2 diabetes who participated in an ongoing prospective study, the Dongfeng-Tongji cohort. Circulating primary and secondary unconjugated BAs and their taurine- or glycine-conjugates were measured using ultraperformance liquid chromatography-tandem mass spectrometry. CKD was defined as eGFR

Details

Language :
English
ISSN :
14752891
Volume :
23
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nutrition Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.596fc38db1ac4ff3bf4ddfe034946222
Document Type :
article
Full Text :
https://doi.org/10.1186/s12937-024-00928-2