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Protective effects of the selective alpha1A-adrenoceptor antagonist silodosin against cyclophosphamide-induced cystitis in rats

Authors :
Nanxi Liu
Shogo Shimizu
Takahiro Shimizu
Kumiko Nakamura
Masaki Yamamoto
Youichirou Higashi
Motoaki Saito
Source :
Journal of Pharmacological Sciences, Vol 132, Iss 1, Pp 71-77 (2016)
Publication Year :
2016
Publisher :
Elsevier, 2016.

Abstract

We investigated the protective effects of a selective α1A-adrenoceptor antagonist, silodosin (Silod) on urinary bladder function in cyclophosphamide (CYP)-induced cystitis rats, with and without desensitization of the capsaicin (CAP)-sensitive afferent nerve pathway. Male Wistar rats (310–400 g) were pretreated with Silod (0, 100, or 300 μg/kg/day, p.o.) for 1 week before cystometry, and were administered either CYP (150 mg/kg, i.p.) or saline 2 days before the experiment. In another experiment, the rats were treated with CAP (125 mg/kg, s.c.) 4 days before the cystometry. The rat bladders were harvested, weighed, and evaluated histologically. The cystometric evaluation showed significant reductions in the intercontraction interval (ICI), single voided volume (SVV), and bladder compliance in CYP-treated rats compared to those in the vehicle-treated rats. High-dose Silod or CAP treatment significantly increased the ICI and SVV in the CYP rats. However, high-dose Silod treatment did not increase the ICI and SVV in CAP-treated CYP rats. Treatment with Silod did not improve the bladder weight, edema, and leukocyte infiltration resulting from the CYP-induced bladder inflammation. These data suggest that blockade of α1-adrenoceptors by Silod inhibited the CAP-sensitive afferent pathway in rats with cystitis.

Details

Language :
English
ISSN :
13478613
Volume :
132
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Pharmacological Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.59c18542c02444158238f0589d29deac
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jphs.2016.08.007