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Effectiveness of perindopril/amlodipine fixed-dose combination in the treatment of hypertension: a systematic review

Authors :
Truong Van Dat
Vo Linh Tu
Le Nguyen Anh Thu
Nguyen Nhat Anh Quang
Van Binh
Nguyen Thi Quynh Nga
Duong Hoang Loc
Tran Thi Hong Nguyen
Dao Ngoc Hien Tam
Hong-Han Huynh
Tran Dinh Trung
Uyen Do
Nguyen Tuan Phat
Dang The Hung
Quang-Hien Nguyen
Nguyen Thi Hai Yen
Le Huu Nhat Minh
Source :
Frontiers in Pharmacology, Vol 14 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

Background: Uncontrolled blood pressure is a major risk factor for cardiovascular diseases. Fixed-dose combination (FDC) therapy offers a promising approach to addressing this challenge by providing a convenient single-tablet solution that enhances the effectiveness of blood pressure control. In our systematic review, we assess the effectiveness of perindopril/amlodipine FDC in managing blood pressure.Methods: We conducted a comprehensive search across four primary electronic databases, namely, PubMed, Virtual Health Library (VHL), Global Health Library (GHL), and Google Scholar, as of 8 February 2022. Additionally, we performed a manual search to find relevant articles. The quality of the selected articles was evaluated using the Study Quality Assessment Tools (SQAT) checklist from the National Institute of Health and the ROB2 tool from Cochrane.Results: Our systematic review included 17 eligible articles. The findings show that the use of perindopril/amlodipine FDC significantly lowers blood pressure and enhances the quality of blood pressure control. Compared to the comparison group, the perindopril/amlodipine combination tablet resulted in a higher rate of blood pressure response and normalization. Importantly, perindopril/amlodipine FDC contributes to improved patient adherence with minimal side effects. However, studies conducted to date have not provided assessments of the cost-effectiveness of perindopril/amlodipine FDC.Conclusion: In summary, our analysis confirms the effectiveness of perindopril/amlodipine FDC in lowering blood pressure, with combination therapy outperforming monotherapy and placebo. Although mild adverse reactions were observed in a small subset of participants, cost-effectiveness assessments for this treatment remain lacking in the literature.

Details

Language :
English
ISSN :
16639812
Volume :
14
Database :
Directory of Open Access Journals
Journal :
Frontiers in Pharmacology
Publication Type :
Academic Journal
Accession number :
edsdoj.5a06479f25b84321883ddfffe37897f2
Document Type :
article
Full Text :
https://doi.org/10.3389/fphar.2023.1156655