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Alternating Magnetic Field Controlled, Multifunctional Nano-Reservoirs: Intracellular Uptake and Improved Biocompatibility

Authors :
GhoshMitra Somesree
Mills Nathaniel
Hynds DiAnna
Diercks David
Cai Tong
Ghosh Santaneel
Source :
Nanoscale Research Letters, Vol 5, Iss 1, Pp 195-204 (2009)
Publication Year :
2009
Publisher :
SpringerOpen, 2009.

Abstract

Abstract Biocompatible magnetic nanoparticles hold great therapeutic potential, but conventional particles can be toxic. Here, we report the synthesis and alternating magnetic field dependent actuation of a remotely controllable, multifunctional nano-scale system and its marked biocompatibility with mammalian cells. Monodisperse, magnetic nanospheres based on thermo-sensitive polymer network poly(ethylene glycol) ethyl ether methacrylate-co-poly(ethylene glycol) methyl ether methacrylate were synthesized using free radical polymerization. Synthesized nanospheres have oscillating magnetic field induced thermo-reversible behavior; exhibiting desirable characteristics comparable to the widely used poly-N-isopropylacrylamide-based systems in shrinkage plus a broader volumetric transition range. Remote heating and model drug release were characterized for different field strengths. Nanospheres containing nanoparticles up to an iron concentration of 6 mM were readily taken up by neuron-like PC12 pheochromocytoma cells and had reduced toxicity compared to other surface modified magnetic nanocarriers. Furthermore, nanosphere exposure did not inhibit the extension of cellular processes (neurite outgrowth) even at high iron concentrations (6 mM), indicating minimal negative effects in cellular systems. Excellent intracellular uptake and enhanced biocompatibility coupled with the lack of deleterious effects on neurite outgrowth and prior Food and Drug Administration (FDA) approval of PEG-based carriers suggest increased therapeutic potential of this system for manipulating axon regeneration following nervous system injury.

Details

Language :
English
ISSN :
19317573 and 1556276X
Volume :
5
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nanoscale Research Letters
Publication Type :
Academic Journal
Accession number :
edsdoj.5a19180d5f804173ae8193beb0de69a6
Document Type :
article
Full Text :
https://doi.org/10.1007/s11671-009-9465-9