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Comparative study between dexmedetomidine and fentanyl for sedation during mechanical ventilation in post-operative paediatric cardiac surgical patients

Authors :
S R Prasad
Parimala Prasanna Simha
A M Jagadeesh
Source :
Indian Journal of Anaesthesia, Vol 56, Iss 6, Pp 547-552 (2012)
Publication Year :
2012
Publisher :
Wolters Kluwer Medknow Publications, 2012.

Abstract

Aims and Objectives: To compare the efficacy of sedation and time taken for extubation using dexmedetomidine and fentanyl sedation in post-operative paediatric cardiac surgical patients. Methods: A prospective randomized double-blind study involving 60 children undergoing open heart surgery was conducted. The patients were divided into two groups, each involving 30 patients. One group received fentanyl at 1 μg/kg/h (Group A) and the other received dexmedetomidine at 0.5 μg/kg/h (Group B) for post-operative sedation with intermittent rescue fentanyl 0.5 μg/kg bolus in either group as per requirement during suctioning. The efficacy of sedation was assessed using the Ramsay sedation score, paediatric intensive care unit sedation score and the tracheal suction score. The time taken for extubation from the stoppage of infusion was noted. Results: Haemodynamic parameters between the two groups were comparable. All sedation scores were comparable in the fentanyl and dexmedetomidine groups. Average time (in minutes) required for extubation was 131.0 (±51.06 SD) in the dexmedetomidine group compared with 373.0 (±121.4 SD) in the fentanyl group. The difference in mean time for extubation was statistically significant. Conclusions: Dexmedetomidine facilitates adequate sedation for mechanical ventilation and also early extubation as compared with fentanyl.

Details

Language :
English
ISSN :
00195049
Volume :
56
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Indian Journal of Anaesthesia
Publication Type :
Academic Journal
Accession number :
edsdoj.5a4eeea55a63432e9e81f29c8f2b11d8
Document Type :
article
Full Text :
https://doi.org/10.4103/0019-5049.104572