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Plasma Metabolome Alterations Discriminate between COVID-19 and Non-COVID-19 Pneumonia

Authors :
Tushar H. More
Bahareh Mozafari
Andre Märtens
Christian Herr
Philipp M. Lepper
Guy Danziger
Thomas Volk
Sabrina Hoersch
Marcin Krawczyk
Katharina Guenther
Karsten Hiller
Robert Bals
Source :
Metabolites, Vol 12, Iss 11, p 1058 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Pneumonia is a common cause of morbidity and mortality and is most often caused by bacterial pathogens. COVID-19 is characterized by lung infection with potential progressive organ failure. The systemic consequences of both disease on the systemic blood metabolome are not fully understood. The aim of this study was to compare the blood metabolome of both diseases and we hypothesize that plasma metabolomics may help to identify the systemic effects of these diseases. Therefore, we profiled the plasma metabolome of 43 cases of COVID-19 pneumonia, 23 cases of non-COVID-19 pneumonia, and 26 controls using a non-targeted approach. Metabolic alterations differentiating the three groups were detected, with specific metabolic changes distinguishing the two types of pneumonia groups. A comparison of venous and arterial blood plasma samples from the same subjects revealed the distinct metabolic effects of pulmonary pneumonia. In addition, a machine learning signature of four metabolites was predictive of the disease outcome of COVID-19 subjects with an area under the curve (AUC) of 86 ± 10%. Overall, the results of this study uncover systemic metabolic changes that could be linked to the etiology of COVID-19 pneumonia and non-COVID-19 pneumonia.

Details

Language :
English
ISSN :
12111058 and 22181989
Volume :
12
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Metabolites
Publication Type :
Academic Journal
Accession number :
edsdoj.5a85c475588346eaadc30512bfb9448f
Document Type :
article
Full Text :
https://doi.org/10.3390/metabo12111058