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The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Osteoarthritis involves whole-joint tissue degeneration. Here, the authors show that miR-204 and miR-211 in mesenchymal joint cells regulate their proliferation, catabolic and osteogenic responses, and that disease progression is ameliorated by intra-articular miR-204 delivery in mice.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5aae4a0d105542e7914d2239eb10e034
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-10753-5