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SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- SARS-CoV-2 variants with spike (S)-protein D614G mutations currently predominate globally. Here, Zhang et al. hypothesize that D614G variant may increase infectivity by increasing S protein abundance on the virion since pseudoviruses carrying S-G614 incorporate higher amounts of S protein and enter cells more efficiently than those carrying S-D614.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5ab81391dfd1486295e3c90c83762edb
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-19808-4