Back to Search
Start Over
A retrospective analysis of real-world outcomes of elderly Chinese patients with diffuse large B-cell lymphoma
- Source :
- Chinese Medical Journal, Vol 132, Iss 15, Pp 1807-1814 (2019)
- Publication Year :
- 2019
- Publisher :
- Wolters Kluwer, 2019.
-
Abstract
- Abstract. Background:. Elderly patients with diffuse large B-cell lymphoma (DLBCL) have a worse prognosis than younger patients, and the optimal treatment strategy for this group remains controversial. We conducted a retrospective analysis to investigate the clinical features and outcomes of elderly patients (>60 years) and to assess the impact of clinical and molecular factors on outcome in this age group. Methods:. From April 2006 to December 2012, a total of 349 elderly patients with DLBCL from the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College were included in this analysis. Patients were further divided into two age groups (61–69 years and ≥70 years). We compared clinical characteristics and outcomes between groups. Results:. Of 349 total patients, 204 (58.5%) were aged 61 to 69 years, and 145 (41.5%) patients were aged 70 years or older. Except for the Eastern Cooperative Oncology Group performance status, clinical characteristics were comparable between the two groups. With a median follow-up of 82 (range, 1–129) months, the 5-year overall survival (OS) and progression-free survival (PFS) rates were 51.9% and 45.8%, respectively. The 5-year OS rates for patients aged 61 to 69 years and those over 70 years were 58.3% and 42.8% (P = 0.007), respectively, and the 5-year PFS rates were 51.0% and 38.6% (P = 0.034). Treatment regimens including rituximab provided a higher 5-year OS rate (63.1% vs. 37.1%, P
- Subjects :
- Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 03666999, 25425641, and 00000000
- Volume :
- 132
- Issue :
- 15
- Database :
- Directory of Open Access Journals
- Journal :
- Chinese Medical Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5b4dd8c95d384d02bd27a29312a8543d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1097/CM9.0000000000000354