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circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis

circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis

Authors :
Minmin Song
Guangfeng Zhao
Haixiang Sun
Simin Yao
Zhenhua Zhou
Peipei Jiang
Qianwen Wu
Hui Zhu
Huiyan Wang
Chenyan Dai
Jingmei Wang
Ruotian Li
Yun Cao
Haining Lv
Dan Liu
Jianwu Dai
Yan Zhou
Yali Hu
Source :
eLife, Vol 10 (2021)
Publication Year :
2021
Publisher :
eLife Sciences Publications Ltd, 2021.

Abstract

Emerging evidence demonstrates the important role of circular RNAs (circRNAs) in regulating pathological processes in various diseases including organ fibrosis. Endometrium fibrosis is the leading cause of uterine infertility, but the role of circRNAs in its pathogenesis is largely unknown. Here, we provide the evidence that upregulation of circPTPN12 in endometrial epithelial cells (EECs) of fibrotic endometrium functions as endogenous sponge of miR-21–5 p to inhibit miR-21–5 p expression and activity, which in turn results in upregulation of ΔNp63α to induce the epithelial mesenchymal transition (EMT) of EECs (EEC–EMT). In a mouse model of endometrium fibrosis, circPTPN12 appears to be a cofactor of driving EEC–EMT and administration of miR-21–5 p could reverse this process and improve endometrial fibrosis. Our findings revealed that the dysfunction of circPTPN12/miR-21–5 p/∆Np63α pathway contributed to the pathogenesis of endometrial fibrosis.

Details

Language :
English
ISSN :
2050084X
Volume :
10
Database :
Directory of Open Access Journals
Journal :
eLife
Publication Type :
Academic Journal
Accession number :
edsdoj.5b72829e3f4949068cbd832373d75130
Document Type :
article
Full Text :
https://doi.org/10.7554/eLife.65735