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Score to assess the probability of relapse in granulomatosis with polyangiitis and microscopic polyangiitis
- Source :
- RMD Open, Vol 9, Iss 1 (2023)
- Publication Year :
- 2023
- Publisher :
- BMJ Publishing Group, 2023.
-
Abstract
- Objective To develop a score assessing the probability of relapse in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA).Methods Long-term follow-up data from GPA and MPA patients included in five consecutive randomised controlled trials were pooled. Patient characteristics at diagnosis were entered into a competing-risks model, with relapse as the event of interest and death the competing event. Univariate and multivariate analyses were computed to identify variables associated with relapse and build a score, which was then validated in an independent cohort of GPA or MPA patients.Results Data collected from 427 patients (203 GPA, 224 MPA) at diagnosis were included. Mean±SD follow-up was 80.6±51.3 months; 207 (48.5%) patients experienced ≥1 relapse. Relapse risk was associated with proteinase 3 (PR3) positivity (HR=1.81 (95% CI 1.28 to 2.57); p
- Subjects :
- Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 20565933
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- RMD Open
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5b834f844e8a4957862a7e73304739a9
- Document Type :
- article
- Full Text :
- https://doi.org/10.1136/rmdopen-2022-002953