Plasma‐derived biomarkers of Alzheimer's disease and neuropsychiatric symptoms: A community‐based study

Authors :: Janina Krell‐Roesch
Isabella Zaniletti
Jeremy A. Syrjanen
Walter K. Kremers
Alicia Algeciras‐Schimnich
Jeffrey L. Dage
Argonde C. vanHarten
Julie A. Fields
David S. Knopman
Clifford R. Jack Jr
Ronald C. Petersen
Maria Vassilaki
Yonas E. Geda
Source :: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 3, Pp n/a-n/a (2023)
Publication Year :: 2023
Publisher :: Wiley, 2023.
Abstract: Abstract INTRODUCTION We examined associations between plasma‐derived biomarkers of Alzheimer's disease (AD) and neuropsychiatric symptoms (NPS) in community‐dwelling older adults. METHODS Cross‐sectional study involving 1005 persons ≥50 years of age (mean 74 years, 564 male, 118 cognitively impaired), who completed plasma‐derived biomarker (amyloid beta 42 [Aβ42]/Aβ40, phosphorylated tau 181 [p‐tau181], p‐tau217, total tau [t‐tau], neurofilament light [NfL]), and NPS assessment. RESULTS P‐tau181 (odds ratio [OR] 2.06, 95% confidence interval [CI] 1.41–3.00, p

Subjects :: Alzheimer's disease
neuropsychiatric symptoms
plasma biomarkers
Neurology. Diseases of the nervous system
RC346-429
Geriatrics
RC952-954.6

Language :: English
ISSN :: 23528729
Volume :: 15
Issue :: 3
Database :: Directory of Open Access Journals
Journal :: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Publication Type :: Academic Journal
Accession number :: edsdoj.5c2a0d36932f4b889296ebf27547267f
Document Type :: article
Full Text :: https://doi.org/10.1002/dad2.12461

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