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Fully Automated, High-Dose Radiosynthesis of [18F]PARPi
- Source :
- Pharmaceuticals, Vol 15, Iss 7, p 865 (2022)
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- [18F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the need to limit the starting activity. The automation of the previously reported protocol for [18F]PARPi synthesis is challenging, as it requires transferring microvolumes of reagents, which many platforms cannot accommodate. We report a revised, high yield, and automated protocol for the radiosynthesis of [18F]PARPi, with final doses of over 20 GBq.
Details
- Language :
- English
- ISSN :
- 14248247
- Volume :
- 15
- Issue :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- Pharmaceuticals
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5c56dea78a23415184e331186f008f9b
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/ph15070865