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Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome
- Source :
- eLife, Vol 5 (2016)
- Publication Year :
- 2016
- Publisher :
- eLife Sciences Publications Ltd, 2016.
-
Abstract
- Human cytomegalovirus (hCMV) immediate early 1 (IE1) protein associates with condensed chromatin of the host cell during mitosis. We have determined the structure of the chromatin-tethering domain (CTD) of IE1 bound to the nucleosome core particle, and discovered that the specific interaction between IE1-CTD and the H2A-H2B acidic patch impairs the compaction of higher-order chromatin structure. Our results suggest that IE1 loosens up the folding of host chromatin during hCMV infections.
Details
- Language :
- English
- ISSN :
- 2050084X
- Volume :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- eLife
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5ccb8aae2824d78a5f7299303ab4d35
- Document Type :
- article
- Full Text :
- https://doi.org/10.7554/eLife.11911