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A Theranostic Nanoprobe for Hypoxia Imaging and Photodynamic Tumor Therapy
- Source :
- Frontiers in Chemistry, Vol 7 (2019)
- Publication Year :
- 2019
- Publisher :
- Frontiers Media S.A., 2019.
-
Abstract
- Hypoxia is a common feature for most malignant tumors, which was also closely related to the oxygen-dependent photodynamic therapy. Based on Förster resonance energy transfer (FRET), a smart nanoprobe (designated as H-Probe) was designed in this paper for hypoxia imaging and photodynamic tumor therapy. Due to the FRET process, H-Probe could respond to hypoxia with a significant fluorescence recovery. Moreover, abundant in vitro investigations demonstrated that the photosensitizer of PpIX in H-Probe could generate large amounts of singlet oxygen to kill cancer cells in the presence of oxygen and light with appropriate wavelength. Also, intravenously injected H-Probe with light irradiation achieved an effective tumor inhibition in vivo with a reduced side effect. This original strategy of integrating hypoxia imaging and tumor therapy in one nanoplatform would promote the development of theranostic nanoplatform for tumor precision therapy.
- Subjects :
- hypoxia
photodynamic therapy
FRET
nanoprobe
theranostic
Chemistry
QD1-999
Subjects
Details
- Language :
- English
- ISSN :
- 22962646
- Volume :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- Frontiers in Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5cd709a80501466e8168ee7a46d16229
- Document Type :
- article
- Full Text :
- https://doi.org/10.3389/fchem.2019.00868