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Solvent-Free, One-Pot, Multicomponent Synthesis of Xanthene Derivatives
- Source :
- Catalysts, Vol 13, Iss 3, p 561 (2023)
- Publication Year :
- 2023
- Publisher :
- MDPI AG, 2023.
-
Abstract
- An efficient and environmentally benign one-pot condensation of cyclic diketones, aldehydes and naphthols was achieved with 1,4-diazabicyclo[2-2-2]octane supported on Amberlyst-15 as a novel catalyst, producing a variety of benzoxanthenones in good to excellent yields. The advantages of this multicomponent reaction include the use of a heterogeneous catalyst, solventless conditions and a simple methodology that is atom-economical and results in low E-factor values. A total of 17 xanthene derivatives, including two novel molecules, were synthesized and then characterized. Aromatic aldehydes carrying an electron-withdrawing group provided excellent yields. Appreciable results were also obtained using aliphatic aldehydes. The catalyst is fully recyclable and can be reused up to six times.
Details
- Language :
- English
- ISSN :
- 20734344
- Volume :
- 13
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Catalysts
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5ce8e55d47a6467cbc25965be85543c7
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/catal13030561