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A novel polyomavirus from the nasal cavity of a giant panda (Ailuropoda melanoleuca)

Authors :
Dunwu Qi
Tongling Shan
Zhijian Liu
Xutao Deng
Zhihe Zhang
Wenlei Bi
Jacob Robert Owens
Feifei Feng
Lisong Zheng
Feng Huang
Eric Delwart
Rong Hou
Wen Zhang
Source :
Virology Journal, Vol 14, Iss 1, Pp 1-6 (2017)
Publication Year :
2017
Publisher :
BMC, 2017.

Abstract

Abstract Background Polyomaviruses infect a wide variety of mammalian and avian hosts with a broad spectrum of outcomes including asymptomatic infection, acute systemic disease, and tumor induction. Methods Viral metagenomics and general PCR methods were used to detected viral nucleic acid in the samples from a diseased and healthy giant pandas. Results A novel polyomavirus, the giant panda polyomavirus 1 (GPPyV1) from the nasal cavity of a dead giant panda (Ailuropoda melanoleuca) was characterized. The GPPyV1 genome is 5144 bp in size and reveals five putative open-reading frames coding for the classic small and large T antigens in the early region, and the VP1, VP2 and VP3 capsid proteins in the late region. Phylogenetic analyses of the large T antigen of the GPPyV1 indicated GPPyV1 belonged to a putative new species within genus Deltapolyomavirus, clustering with four human polyomavirus species. The GPPyV1 VP1 and VP2 clustered with genus Alphapolyomavirus. Our epidemiologic study indicated that this novel polyomavirus was also detected in nasal swabs and fecal samples collected from captive healthy giant pandas. Conclusion A novel polyomavirus was detected in giant pandas and its complete genome was characterized, which may cause latency infection in giant pandas.

Details

Language :
English
ISSN :
1743422X
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Virology Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.5d5095a9779741d781da7f77375e5846
Document Type :
article
Full Text :
https://doi.org/10.1186/s12985-017-0867-5