Risk factors for infection of Morganella morganii β-lactamase positive strains in type 2 diabetes patients with diabetic foot

ObjectiveTo explore the drug resistance of Morganella morganii (Mm) and the risk factors for extended-spectrum β-lactamase (ESBL) positive infection in type 2 diabetes foot (DF) patients with Mm, and to provide a reference for clinical treatment.Methods310 samples of DF patients with Mm infection were collected from Shanghai Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2020 to March 2023. The patients were selected for the first time to detect Mm bacteria through cultivation, and were divided into ESBL producing group (n=45) and non ESBL producing group (n=265). Bacterial identification and drug sensitivity experiments on Mm were conducted. Multivariate logistic regression analysis was used to analyze the risk factors. The stepwise regression method (SRM) was used to screen the most important correlation factors for constructing risk prediction model and its evaluation.ResultsBoth ESBL producing and non ESBL producing Mm were sensitive to imipenem (IPM) and meropenem (MEM). Compared with the non ESBL producing group, the resistance of Mm in the ESBL producing group to other tested antibiotics [excluding ampicillin (AM)/sulbactam (SU)] was higher (P