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Multiple Viral microRNAs Regulate Interferon Release and Signaling Early during Infection with Epstein-Barr Virus

Authors :
Mickaël Bouvet
Stefanie Voigt
Takanobu Tagawa
Manuel Albanese
Yen-Fu Adam Chen
Yan Chen
Devin N. Fachko
Dagmar Pich
Christine Göbel
Rebecca L. Skalsky
Wolfgang Hammerschmidt
Source :
mBio, Vol 12, Iss 2 (2021)
Publication Year :
2021
Publisher :
American Society for Microbiology, 2021.

Abstract

Acute antiviral functions of all nucleated cells rely on type I interferon (IFN-I) pathways triggered upon viral infection. Host responses encompass the sensing of incoming viruses, the activation of specific transcription factors that induce the transcription of IFN-I genes, the secretion of different IFN-I types and their recognition by the heterodimeric IFN-α/β receptor, the subsequent activation of JAK/STAT signaling pathways, and, finally, the transcription of many IFN-stimulated genes (ISGs).

Subjects

Subjects :
Microbiology
QR1-502

Details

Language :
English
ISSN :
21507511
Volume :
12
Issue :
2
Database :
Directory of Open Access Journals
Journal :
mBio
Publication Type :
Academic Journal
Accession number :
edsdoj.5df41ff7727d458eb1c5cf6678139f31
Document Type :
article
Full Text :
https://doi.org/10.1128/mBio.03440-20