Serum bilirubin to fetuin-A ratio as a prognostic biomarker in critically ill patients with sepsis

Liver dysfunction during sepsis is associated with increased bilirubin and decreased fetuin-A, a major hepatokine. We aimed to explore the association of bilirubin to fetuin-A (B/F) ratio early in sepsis with severity and outcome in critically ill patients. Based on a previous prospective study, we analyzed data of 90 critically ill patients (52 males, age: 65 ± 15 years, APACHE II: 24 ± 7 and SOFA: 10 ± 3) with sepsis. Bilirubin and fetuin-A increased during the first week of sepsis, (median (IQR) 0.45 (0.32–1) vs 0.55 (0.29–0.78) mg/dL, p = 0.03 and 302 (248–336) vs 358 (307–399) μg/mL, p