Sorry, I don't understand your search. ×
Back to Search Start Over

The role of ferroptosis in central nervous system damage diseases

Authors :
Mingzhu Li
Shengbo Jin
Xudong Zhu
Jian Xu
Yang Cao
Haozhe Piao
Source :
PeerJ, Vol 12, p e16741 (2024)
Publication Year :
2024
Publisher :
PeerJ Inc., 2024.

Abstract

Ferroptosis is a form of cell death, i.e., programmed cell death characterized by lipid peroxidation and iron dependence, which has unique morphological and biochemical properties. This unique mode of cell death is driven by iron-dependent phospholipid peroxidation and regulated by multiple cell metabolic pathways, including redox homeostasis, iron metabolism, mitochondrial activity, and the metabolism of amino acids, lipids, and sugars. Many organ injuries and degenerative pathologies are caused by ferroptosis. Ferroptosis is closely related to central nervous system injury diseases and is currently an important topic of research globally. This research examined the relationships between ferroptosis and the occurrence and treatment of central nervous system injury diseases. Additionally, ferroptosis was assessed from the aspect of theory proposal, mechanism of action, and related signaling pathways per recent research. This review provides a relevant theoretical basis for further research on this theory, the prospect of its development, and the prevention and treatment of such diseases.

Details

Language :
English
ISSN :
21678359
Volume :
12
Database :
Directory of Open Access Journals
Journal :
PeerJ
Publication Type :
Academic Journal
Accession number :
edsdoj.5e963d061612403580fc1d14d3243127
Document Type :
article
Full Text :
https://doi.org/10.7717/peerj.16741