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Does perioperative oxandrolone improve nutritional status in patients with cachexia related to head and neck carcinoma?

Authors :
Angela M. Osmolak
Cristine N. Klatt‐Cromwell
Amber M. Price
Jose A. Sanclement
Greg A. Krempl
Source :
Laryngoscope Investigative Otolaryngology, Vol 4, Iss 3, Pp 314-318 (2019)
Publication Year :
2019
Publisher :
Wiley, 2019.

Abstract

Background Cancer cachexia affects up to over 50% of advanced head and neck cancer (HNC) patients. To date, the potential utility of anabolic steroids in perioperative cachectic HNC patients has not been determined. Methods Retrospective review of pre‐ and post‐oxandrolone administration prealbumin levels in 18 perioperative HNC patients between October 2007 and October 2014 at a tertiary academic medical center. Results The median pretreatment prealbumin was 88.5 mg/L. The median post‐treatment prealbumin was 227 mg/L. The median interval improvement of the prealbumin level was 131.5 mg/L. The median differences between the pretreatment and post‐treatment prealbumin levels were found to be statistically significant (P

Details

Language :
English
ISSN :
23788038
Volume :
4
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Laryngoscope Investigative Otolaryngology
Publication Type :
Academic Journal
Accession number :
edsdoj.5eedb6a79b0440049a8e72e09b8d122d
Document Type :
article
Full Text :
https://doi.org/10.1002/lio2.268