Transcription factor enrichment analysis (TFEA) quantifies the activity of multiple transcription factors from a single experiment

Rubin et al. introduce transcription factor enrichment analysis (TFEA), a new motif enrichment method specifically aimed at maximizing the informative nature of differential RNA polymerase initiation data. It provides an easy, rigorous, and cost-effective analysis aimed at deciphering the temporal and mechanistic details of complex regulatory networks.