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Information Transmission in G Protein-Coupled Receptors

Authors :
Roger D. Jones
Source :
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1621 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

G protein-coupled receptors (GPCRs) are the largest class of receptors in the human genome and constitute about 30% of all drug targets. In this article, intended for a non-mathematical audience, both experimental observations and new theoretical results are compared in the context of information transmission across the cell membrane. The amount of information actually currently used or projected to be used in clinical settings is a small fraction of the information transmission capacity of the GPCR. This indicates that the number of yet undiscovered drug targets within GPCRs is much larger than what is currently known. Theoretical studies with some experimental validation indicate that localized heat deposition and dissipation are key to the identification of sites and mechanisms for drug action.

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
25
Issue :
3
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.5f65b8139ff34e1ca04fe9add8aa9cb4
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms25031621