Back to Search Start Over

Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol‐Induced Liver Damage

Authors :
Jeremy P. Koelmel
Wan Y. Tan
Yang Li
John A. Bowden
Atiye Ahmadireskety
Andrew C. Patt
David J. Orlicky
Ewy Mathé
Nicholas M. Kroeger
David C. Thompson
Jason A. Cochran
Jaya Prakash Golla
Aikaterini Kandyliari
Ying Chen
Georgia Charkoftaki
Joy D. Guingab‐Cagmat
Hiroshi Tsugawa
Anmol Arora
Kirill Veselkov
Shunji Kato
Yurika Otoki
Kiyotaka Nakagawa
Richard A. Yost
Timothy J. Garrett
Vasilis Vasiliou
Source :
Hepatology Communications, Vol 6, Iss 3, Pp 513-525 (2022)
Publication Year :
2022
Publisher :
Wolters Kluwer Health/LWW, 2022.

Abstract

Alcoholic fatty liver disease (AFLD) is characterized by lipid accumulation and inflammation and can progress to cirrhosis and cancer in the liver. AFLD diagnosis currently relies on histological analysis of liver biopsies. Early detection permits interventions that would prevent progression to cirrhosis or later stages of the disease. Herein, we have conducted the first comprehensive time‐course study of lipids using novel state‐of‐the art lipidomics methods in plasma and liver in the early stages of a mouse model of AFLD, i.e., Lieber‐DeCarli diet model. In ethanol‐treated mice, changes in liver tissue included up‐regulation of triglycerides (TGs) and oxidized TGs and down‐regulation of phosphatidylcholine, lysophosphatidylcholine, and 20‐22‐carbon‐containing lipid‐mediator precursors. An increase in oxidized TGs preceded histological signs of early AFLD, i.e., steatosis, with these changes observed in both the liver and plasma. The major lipid classes dysregulated by ethanol play important roles in hepatic inflammation, steatosis, and oxidative damage. Conclusion: Alcohol consumption alters the liver lipidome before overt histological markers of early AFLD. This introduces the exciting possibility that specific lipids may serve as earlier biomarkers of AFLD than those currently being used.

Details

Language :
English
ISSN :
2471254X
Volume :
6
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Hepatology Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.5f7be9683684d59b0c25b597814b71a
Document Type :
article
Full Text :
https://doi.org/10.1002/hep4.1825