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Causal association between snoring and stroke: a Mendelian randomization study in a Chinese populationResearch in context
- Source :
- The Lancet Regional Health. Western Pacific, Vol 44, Iss , Pp 101001- (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- Summary: Background: Previous observational studies established a positive relationship between snoring and stroke. We aimed to investigate the causal effect of snoring on stroke. Methods: Based on 82,339 unrelated individuals with qualified genotyping data of Asian descent from the China Kadoorie Biobank (CKB), we conducted a Mendelian randomization (MR) analysis of snoring and stroke. Genetic variants identified in the genome-wide association analysis (GWAS) of snoring in CKB and UK Biobank (UKB) were selected for constructing genetic risk scores (GRS). A two-stage method was applied to estimate the associations of the genetically predicted snoring with stroke and its subtypes. Besides, MR analysis among the non-obese group (body mass index, BMI
Details
- Language :
- English
- ISSN :
- 26666065
- Volume :
- 44
- Issue :
- 101001-
- Database :
- Directory of Open Access Journals
- Journal :
- The Lancet Regional Health. Western Pacific
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5ff4922d45fb49c1a5598163d5c19d41
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.lanwpc.2023.101001