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The Regulation of Human β-Defensin 2 by the ETS Transcription Factor MEF (Myeloid Elf-1-Like Factor) Is Enhanced by Promyelocytic Leukemia Protein
- Source :
- Journal of Pharmacological Sciences, Vol 95, Iss 4, Pp 466-470 (2004)
- Publication Year :
- 2004
- Publisher :
- Elsevier, 2004.
-
Abstract
- The human β-defensin 2 (HBD 2) is a potent anti-bacterial peptide with a wide spectrum of activity. MEF (myeloid elf-1-like factor) or Elf4, a member of the ETS transcription factor family, has been shown to up-regulate the basal expression of the HBD 2 gene in epithelial cells. The mammalian cell nucleus is organized into distinct nuclear domains, one of which is the PML (promyelocytic leukemia) nuclear body involved in the regulation of transcription. Here, we show that PML stimulated MEF transcriptional activity, resulting in the up-regulation of endogenous HBD 2 expression. Keywords:: β-defensin 2, myeloid elf-1-like factor, promyelocytic leukemia nuclear body
- Subjects :
- Therapeutics. Pharmacology
RM1-950
Subjects
Details
- Language :
- English
- ISSN :
- 13478613
- Volume :
- 95
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Pharmacological Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.5ffbe7bb82e041d7a852d67b63317b8b
- Document Type :
- article
- Full Text :
- https://doi.org/10.1254/jphs.sc0040077