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Heterologous COVID-19 Booster Vaccination in the Chronic Disorder of Consciousness: A Pilot Study

Authors :
Maria Elena Pugliese
Riccardo Battaglia
Maria Girolama Raso
Raffaela Chiaravalloti
Francesco Coschignano
Angela Pagliuso
Roberta Bruschetta
Giovanni Pugliese
Paolo Scola
Paolo Tonin
Antonio Cerasa
Source :
Clinics and Practice, Vol 12, Iss 3, Pp 318-325 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Significant anti-spike protein receptor-binding domain (S-RBD) antibody responses have been demonstrated in patients with chronic disorder of consciousness (DOC) completing a COVID-19 vaccine regime with BNT162b2 (Pfizer–BioNTech). We now provide further prospective data on the immunogenicity of these patients followed by heterologous booster injection with mRNA-1273 (Moderna). These patients were compared with two different demographically comparable healthcare workers (HCW) groups who underwent homologous booster injection with BNT162b2 vaccine or heterologous booster injection with mRNA-1273. Antibody responses were evaluated at 21 days after the administration of the booster dose of vaccination. Results: No severe adverse reactions were reported after each type of vaccination. Heterologous boosting with mRNA-1273 elicited a higher increase of S-RBD IgG levels than homologous boosting with BNT162b2 both in DOC patients and HCW who had previously received two doses of BNT162b2. No significant difference was detected between DOC and HCW patients who received heterologous boosting. Conclusions: Despite the small sample size, our preliminary results suggest that heterologous boosting with mRNA-1273, following initial vaccination with BNT162b2, is safe and tends to be more immunogenic than homologous boosting, either in fragile people or in healthy controls.

Details

Language :
English
ISSN :
20397283
Volume :
12
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Clinics and Practice
Publication Type :
Academic Journal
Accession number :
edsdoj.6011650370664928be6b7c2baf105952
Document Type :
article
Full Text :
https://doi.org/10.3390/clinpract12030037