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Long-Lasting Enhanced Cytokine Responses Following SARS-CoV-2 BNT162b2 mRNA Vaccination

Authors :
Georgiana Cabău
Medeea Badii
Andreea M. Mirea
Orsolya I. Gaal
Liesbeth van Emst
Radu A. Popp
Tania O. Crișan
Leo A. B. Joosten
Source :
Vaccines, Vol 12, Iss 7, p 736 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

The mRNA vaccine against COVID-19 protects against severe disease by the induction of robust humoral and cellular responses. Recent studies have shown the capacity of some vaccines to induce enduring non-specific innate immune responses by the induction of trained immunity, augmenting protection against unrelated pathogens. This study aimed to assess whether the mRNA vaccine BNT162b2 can induce lasting non-specific immune responses in myeloid cells following a three-dose vaccination scheme. In a sample size consisting of 20 healthy individuals from Romania, we assessed inflammatory proteins using the Olink® Target 96 Inflammation panel, as well as ex vivo cytokine responses following stimulations with unrelated PRR ligands. We assessed the vaccine-induced non-specific systemic inflammation and functional adaptations of myeloid cells. Our results revealed the induction of a stimulus- and cytokine-dependent innate immune memory phenotype that became apparent after the booster dose and was maintained eight months later in the absence of systemic inflammation.

Details

Language :
English
ISSN :
2076393X
Volume :
12
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Vaccines
Publication Type :
Academic Journal
Accession number :
edsdoj.60953f5bbf2045ba8bb35236bd19efd1
Document Type :
article
Full Text :
https://doi.org/10.3390/vaccines12070736