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Investigating Holistic Natural Strategies for The Management of Huntington's Disease

Authors :
Silakari Pragati
Yadav Aditi
Arora Aneesha
Arora Anushka
Gulsheen
Kaur Paranjeet
Kumar Sahu Sanjeev
Source :
BIO Web of Conferences, Vol 86, p 01041 (2024)
Publication Year :
2024
Publisher :
EDP Sciences, 2024.

Abstract

Huntington's disease (HD), a multifaceted neurological disorder, presents a complex clinical scenario. An autosomal dominant neurodegenerative ailment called Huntington's disease is brought on by increase in number of CAG (Cytosine-Adenine-Guanine) repeats, which causes the creation of a mutant Huntingtin protein (mHTT) resulting in neuronal death and mental disabilities in human beings. End signs and symptoms can include significant weight loss, difficulty swallowing or breathing, recurrent aspiration pneumonia, declined health and uncontrolled pain. The excessive production of ROS (Reactive Oxygen Species) in nervous tissues is considered a significant risk factor in most of the neurological diseases including HD. Transcriptional regulation, immunological system, and mitochondrial function are all disrupted by mHTT. Although natural products have shown promise in ameliorating symptoms, it is important to note that no singular "phytoconstituent" has been definitively linked to its therapeutic intervention. Nevertheless, certain naturally occurring compounds have exhibited promising outcomes in preclinical investigations. This article focuses on a few phytoconstituents that are known to have a variety of neuroprotective effects through a wide range of biological activities. By stimulating the Nrf2 (Nuclear factor erythroid 2-related factor) pathway and suppressing NF-κB (Nuclear Factor Kappa-light-chain-enhancer of activated B cells), astaxanthin, berberine, and sulfarophane increase the antioxidant and anti-inflammatory activity, resulting in neuroprotection. Curcumin leads to metal chelating effect and decline in reactive oxygen species which are certainly one among the vital processes to impede and manage the disorders causing neurodegeneration including HD. This affects the upregulation of HSPs (Heat Shock Proteins) which helps in HD management. Naringin reduces level of oxidative stress and inflammation by free radical scavenging, NF-κB stimulates cell survival and prevents apoptosis by upregulating anti-apoptotic genes expression and downregulating proapoptotic genes.

Details

Language :
English, French
ISSN :
21174458 and 20248601
Volume :
86
Database :
Directory of Open Access Journals
Journal :
BIO Web of Conferences
Publication Type :
Academic Journal
Accession number :
edsdoj.60fbb9e396474191af9f972bb6ed369a
Document Type :
article
Full Text :
https://doi.org/10.1051/bioconf/20248601041