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Clinical study of Wnt inhibitory factor-1 expression and its association with disease severity in non-segmental vitiligo
- Source :
- Beni-Suef University Journal of Basic and Applied Sciences, Vol 13, Iss 1, Pp 1-8 (2024)
- Publication Year :
- 2024
- Publisher :
- SpringerOpen, 2024.
-
Abstract
- Abstract Background Vitiligo is classified as an acquired chronic depigmentation disorder that includes the destruction of epidermal melanocytes. It affects 0.5–1% of the population all over the world. Wnt signaling pathway is vital in melanocytes differentiation and development. WIF-1 is an antagonist of the Wnt signaling pathway; it hinders Wnt from binding its receptors. The present study aims to detect WIF-1 expression in vitiligo skin and if it relates to the disease's severity. Results This case–control study included 70 subjects: 35 vitiligo patients and 35 healthy controls. Skin WIF-1 expression was estimated using quantitative real-time PCR. Assessment of the vitiligo disease activity score and vitiligo area severity index score was determined. WIF-1 expression showed significant elevation in the skin of vitiligo patients compared to the healthy control group. Conclusion Overexpression of WIF-1 may participate in the pathogenesis of vitiligo; hence, it should be a future therapeutic target.
Details
- Language :
- English
- ISSN :
- 23148543
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Beni-Suef University Journal of Basic and Applied Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.613bced67cb64cdd93700eb3cdcc7b89
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s43088-024-00549-y