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Association between Vitamin Intake and Chronic Kidney Disease According to a Variant Located Upstream of the PTGS1 Gene: A Cross-Sectional Analysis of Shika Study

Authors :
Kim-Oanh Pham
Akinori Hara
Hiromasa Tsujiguchi
Keita Suzuki
Fumihiko Suzuki
Sakae Miyagi
Takayuki Kannon
Takehiro Sato
Kazuyoshi Hosomichi
Hirohito Tsuboi
Thao Thi Thu Nguyen
Yukari Shimizu
Yasuhiro Kambayashi
Masaharu Nakamura
Chie Takazawa
Haruki Nakamura
Toshio Hamagishi
Aki Shibata
Tadashi Konoshita
Atsushi Tajima
Hiroyuki Nakamura
Source :
Nutrients, Vol 14, Iss 10, p 2082 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Chronic kidney disease (CKD) patients have been advised to take vitamins; however, the effects have been controversial. The individual differences in developing CKD might involve genetic variants of inflammation, including variant rs883484 located upstream of the prostaglandin-endoperoxide synthase 1 (PTGS1) gene. We aimed to identify whether the 12 dietary vitamin intake interacts with genotypes of the rs883484 on developing CKD. The population-based, cross-sectional study had 684 Japanese participants (≥40 years old). The study used a validated, brief, self-administered diet history questionnaire to estimate the intake of the dietary vitamins. CKD was defined as estimated glomerular filtration < 60 mL/min/1.73 m2. The study participants had an average age of 62.1 ± 10.8 years with 15.4% minor homozygotes of rs883484, and 114 subjects had CKD. In the fully adjusted model, the higher intake of vitamins, namely niacin (odds ratio (OR) = 0.74, 95% confidence interval (CI): 0.57–0.96, p = 0.024), α-tocopherol (OR = 0.49, 95% CI: 0.26–0.95, p = 0.034), and vitamin C (OR = 0.97, 95% CI: 0.95–1.00, p = 0.037), was independently associated with lower CKD tendency in the minor homozygotes of rs883484. The results suggested the importance of dietary vitamin intake in the prevention of CKD in middle-aged to older-aged Japanese with minor homozygous of rs883484 gene variant.

Details

Language :
English
ISSN :
20726643
Volume :
14
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
edsdoj.6160359aa1ca4181ac2c38f7f5863dc2
Document Type :
article
Full Text :
https://doi.org/10.3390/nu14102082