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Association of pathway mutation with survival after recurrence in colorectal cancer patients treated with adjuvant fluoropyrimidine and oxaliplatin chemotherapy

Authors :
Dae-Won Lee
Sae-Won Han
Yongjun Cha
Jeong Mo Bae
Hwang-Phill Kim
Jaemyun Lyu
Hyojun Han
Hyoki Kim
Hoon Jang
Duhee Bang
Jae-Kyung Won
Seung-Yong Jeong
Kyu Joo Park
Gyeong Hoon Kang
Tae-You Kim
Source :
BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)
Publication Year :
2019
Publisher :
BMC, 2019.

Abstract

Abstract Background Although the prognostic biomarkers associated with colorectal cancer (CRC) survival are well known, there are limited data on the association between the molecular characteristics and survival after recurrence (SAR). The purpose of this study was to assess the association between pathway mutations and SAR. Methods Of the 516 patients with stage III or high risk stage II CRC patients treated with surgery and adjuvant chemotherapy, 87 who had distant recurrence were included in the present study. We analyzed the association between SAR and mutations of 40 genes included in the five critical pathways of CRC (WNT, P53, RTK-RAS, TGF-β, and PI3K). Results Mutation of genes within the WNT, P53, RTK-RAS, TGF-β, and PI3K pathways were shown in 69(79.3%), 60(69.0%), 57(65.5%), 21(24.1%), and 19(21.8%) patients, respectively. Patients with TGF-β pathway mutation were younger and had higher incidence of mucinous adenocarcinoma (MAC) histology and microsatellite instability-high. TGF-β pathway mutation (median SAR of 21.6 vs. 44.4 months, p = 0.021) and MAC (20.0 vs. 44.4 months, p = 0.003) were associated with poor SAR, and receiving curative resection after recurrence was associated with favorable SAR (Not reached vs. 23.6 months, p

Details

Language :
English
ISSN :
14712407
Volume :
19
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Cancer
Publication Type :
Academic Journal
Accession number :
edsdoj.6160588d637b430f94fc80d647175466
Document Type :
article
Full Text :
https://doi.org/10.1186/s12885-019-5650-0