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Helicobacter pylori initiates successful gastric colonization by utilizing L-lactate to promote complement resistance

Authors :
Shuai Hu
Karen M. Ottemann
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

The complement system is a key protective response against infectious pathogens. Here, the authors show that Helicobacter pylori uses host L-lactate to generate a complement resistant state that promotes gastric colonisation.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.61be460eb1948d88915664a4b40e846
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-37160-1