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Intestinal homeostasis: a communication between life and death
- Source :
- Cell & Bioscience, Vol 10, Iss 1, Pp 1-3 (2020)
- Publication Year :
- 2020
- Publisher :
- BMC, 2020.
-
Abstract
- Abstract Organ homeostasis is essential for organ physiology and disease prevention. In adult vertebrates, the intestinal epithelium is maintained through constant cell proliferation in the crypt and apoptosis of differentiated epithelial cells, mainly at the tip of the villus. Based on studies with altered cell proliferation and tissue damage in the adult mouse intestine, we hypothesize that there is a communication between cell proliferation in the crypt and cell death on the villus, likely via cell–cell and cell-ECM (extracellular matrix) interactions, to coordinate the rate of cell proliferation and death, thus ensuring epithelial homeostasis.
Details
- Language :
- English
- ISSN :
- 20453701
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Cell & Bioscience
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6238873436cd4c4982ac34ce78860aee
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s13578-020-00429-9