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To Investigate the Occurrence and Development of Colorectal Cancer Based on the PI3K/AKT/mTOR Signaling Pathway
- Source :
- Frontiers in Bioscience-Landmark, Vol 28, Iss 2, p 37 (2023)
- Publication Year :
- 2023
- Publisher :
- IMR Press, 2023.
-
Abstract
- Colorectal cancer (CRC) is the most common malignancy of the gastrointestinal, however, the underlying mechanisms of CRC remain largely unknown. New evidence suggests that the PI3K/AKT/mTOR pathway is closely related to CRC. PI3K/AKT/mTOR is a classical signaling pathway that is involved in a variety of biological processes, such as regulating cellular metabolism, autophagy, cell cycle progression, cell proliferation, apoptosis, and metastasis. Therefore, it plays a crucial role in the occurrence and development of CRC. In this review, we focus on the role of the PI3K/AKT/mTOR pathway in CRC, and its application of to the treatment of CRC. We review the importance of the PI3K/AKT/mTOR signaling pathway in tumorigenesis, proliferation and progression, and pre-clinical and clinical experience with several PI3K/AKT/mTOR pathway inhibitors in CRC.
Details
- Language :
- English
- ISSN :
- 27686701
- Volume :
- 28
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Frontiers in Bioscience-Landmark
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6282eee5f70741209c7a0059a82ff6ab
- Document Type :
- article
- Full Text :
- https://doi.org/10.31083/j.fbl2802037