Back to Search Start Over

The Role and Function of TRPM8 in the Digestive System

Authors :
Zunan Wu
Shuai Peng
Wensha Huang
Yuling Zhang
Yashi Liu
Xiaoyun Yu
Lei Shen
Source :
Biomolecules, Vol 14, Iss 7, p 877 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Transient receptor potential (TRP) melastatin member 8 (TRPM8) is a non-selective cation channel that can be activated by low temperatures (8–26 °C), cooling agents (including menthol analogs such as menthol, icilin, and WS-12), voltage, and extracellular osmotic pressure changes. TRPM8 expression has been identified in the digestive system by several research teams, demonstrating its significant involvement in tissue function and pathologies of the digestive system. Specifically, studies have implicated TRPM8 in various physiological and pathological processes of the esophagus, stomach, colorectal region, liver, and pancreas. This paper aims to comprehensively outline the distinct role of TRPM8 in different organs of the digestive system, offering insights for future mechanistic investigations of TRPM8. Additionally, it presents potential therapeutic targets for treating conditions such as digestive tract inflammation, tumors, sensory and functional disorders, and other related diseases. Furthermore, this paper addresses the limitations of existing studies and highlights the research prospects associated with TRPM8.

Details

Language :
English
ISSN :
2218273X
Volume :
14
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Biomolecules
Publication Type :
Academic Journal
Accession number :
edsdoj.62d4100cd3a14714ba1e02a555a94303
Document Type :
article
Full Text :
https://doi.org/10.3390/biom14070877