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A biosensor-based framework to measure latent proteostasis capacity
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- A pool of quality control proteins (QC) maintains the protein-folding homeostasis in the cell, but its quantitative analysis is challenging. Here the authors develop a FRET sensor based on the protein barnase, able to quantify QC holdase activity and its ability to suppress protein aggregation.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6391112b918e4b36a3854c8ea904fe80
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-017-02562-5