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A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions

Authors :
Krishnan MohanKumar
Kopperuncholan Namachivayam
Tanjing Song
Byeong Jake Cha
Andrea Slate
Jeanne E. Hendrickson
Hua Pan
Samuel A. Wickline
Joo-Yeun Oh
Rakesh P. Patel
Ling He
Benjamin A. Torres
Akhil Maheshwari
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

The development of neonatal necrotising enterocolitis has been temporally associated with red blood cell transfusions in retrospective human studies. Here, the authors develop a neonatal mouse model of necrotising enterocolitis in anaemic mice receiving red blood cell transfusion that recapitulates features of the human condition.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723 and 34862293
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.6410e0e9afc14c3486229368579878f2
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-11199-5